2025
Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities
Optogenetics allows versatile control of excitable cell networks, which advances basic science research and drives the development of future medical applications. Fast-closing channelrhodopsins (ChRs) are required for high temporal fidelity of neurostimulation, but their short channel open times require sufficient plasma membrane expression and high light intensity, challenging clinical translation.
Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins with Light
Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light (2025) Zipf D, Vogt M, Sathyanarayanan U, Wagdi A, Riebeling J, Patejdl R, Bruegmann T. Neurogastroenterol Motil.
International Expert Consensus on Gene Therapy for Hereditary Hearing Loss: Based on Clinical Trials
Fan X et al. International Expert Consensus on Gene Therapy for Hereditary Hearing Loss: Based on Clinical Trials. MED 2025
Charting the Nanotopography of Inner Hair Cell Synapses Using MINFLUX Nanoscopy
Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy (2025) Rohan Kapoor, Hyojin Kim, Evelyn Garlick, Maria Augusta do R. B. F. Lima, Klara Esch, Torben Ruhwedel, Wiebke Möbius, Fred Wolf, Tobias Moser. Science Advances
Isotropic, Aberration-Corrected Light Sheet Microscopy for Rapid High-Resolution Imaging of Cleared Tissue
Aakhte, M et al. Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue. Nat Biotech 2025
Visual objects refine head direction coding
Visual objects refine head direction coding (2025) Dominique Siegenthaler, Henry Denny, Sofía Skromne Carrasco, Johanna Luise Mayer, Daniel Levenstein, Adrien Peyrache, Stuart Trenholm und Emilie Macé. Science
Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry
Vona, B et al. Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry. MedComm 2025
Gastric Pacemaker Update: Relevance for Gastroparesis
Gastric Pacemaker Update: Relevance for Gastroparesis (2025) Riebeling J, Patejdl R, Zipf D, Conradi LC, Ghadimi M, Gundling F, Bruegmann T., Zentralbl Chir. 337-345. [Update on Gastric Pacemaking: Relevance for Gastroparesis]
Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system
Jablonski, L et al. Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system. J Neural Eng 2025
Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing
Chen, H et al. Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing. Sci Adv 2025
Efficient and Sustained Optogenetic Control of Sensory and Cardiac Systems
Alekseev, A et al. Efficient and sustained optogenetic control of sensory and cardiac systems. Nat Biomed Eng 2025
3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography
Schaeper, JJ et al. 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography. Sci Rep 2025
CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy
Roos, L et al. CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy. bioRxiv 2025
Toward Elucidating the Mechanism of Cochlear Stimulation by Infrared Light
Moser, T & Roos, L. Toward elucidating the mechanism of cochlear stimulation by infrared light. PNAS 2025 (invited news and views)
CryoRhodopsins: a Comprehensive Characterization of a Group of Microbial Rhodopsins from Cold Environments
Lamm, GHU*, Marin, E*, Alekseev, A* et al. CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments. Sci. Adv. 2025
Improved Optogenetic Modification of Spiral Ganglion Neurons for Future Optical Cochlear Implants
Thirumalai et al. Improved optogenetic modification of spiral ganglion neurons for future optical cochlear implants. Theranostics 2025
