Dear Ladies and Gentlemen,
We cordially invite you to the next EKFZ Guest Lecture:
Dr. Magdalena Renner: High-throughput Retinal Organoids for Therapeutic Development
Date and time:
November 5, 2025, 4:00 PM
Location:
Lecture hall of the DPZ (Kellnerweg 4, 37077 Göttingen)
Abstract:
Retinal organoids are a 3D in vitro model of the human retina that models its cell type diversity, arrangement, transcriptome, and functional aspects. Although human retinal organoids require 30 weeks to mature, we have established methods to use them for high-content screening of adeno-associated viral vectors (AAV). Our goal is to identify regulatory elements that lead to AAV-driven gene expression exclusively in specific cell types of the human retina. Cell type-specific gene expression is important to minimize toxicity caused by off-target expression of gene therapy vectors. Furthermore, cell type-specific transgene expression provides access to specific cells for basic research in various model systems. Beyond the retina, the methods we have developed are broadly applicable across the entire field of organoid research: We use cost-effective laboratory automation for high-throughput organoid generation, maintenance, and screening, and have increased the throughput of organoid cryosectioning and histology with the HistoBrick array format.
Prof. Dr. Emilie Macé will receive the speaker. If you would like to meet Magdalena Renner before the lecture, please contact Emilie by email (emilie.mace@med.uni-goettingen.de).
Please feel free to forward this announcement and information flyer to anyone who might be interested.
Best regards,
Marie
