We cordially invite you to the next EKFZ guest lecture:
Prof. Dr. Christoph Arnoldner & Dr. Erdem Yildiz: Translational Hearing Research – Examples of the Path from the Laboratory to the Patient
Date & Time: January 7, 2026, 4:00 PM
Location: Lecture Hall 04 of the UMG (Robert-Koch-Str. 40, 37075 Göttingen)
Abstract:
This lecture presents a translational research program that includes in vitro experiments, rodent models, and large animal studies, culminating in early clinical applications for sensorineural hearing loss of various causes. Potential drug formulations – such as the promising pyridoindole compound AC102 – are initially investigated in ex vivo cochlea explant cultures and then tested in a gerbil model for cochlear implant trauma to assess functional recovery. Compounds that show a robust effect are then tested in a pig model, which is very similar to the human inner ear in size and surgical anatomy and allows a detailed analysis of the pathophysiology and intracochlear pharmacokinetics.
We also investigate cochlear implants – the most commonly used neuroprostheses worldwide – with a focus on optimizing atraumatic electrode insertion and comparing different strategies for local drug delivery. In parallel, we are exploring a “liquid biopsy” approach by analyzing perilymph biomarkers that can provide insights into the mechanisms underlying hearing loss.
The translational path extends into early clinical practice, including initial experiences with local intracochlear drug injection and robot-assisted, low-trauma cochlear implantation. Finally, we discuss gene-based interventions, highlighting ongoing industry-sponsored clinical trials for OTOF-related congenital deafness in children, supported by complementary pig models for future gene therapy development. Together, these studies outline a continuous pipeline from basic discovery to patient-ready treatments.
Prof. Dr. Dirk Beutner will welcome the speakers.
