{"id":9083,"date":"2026-03-04T12:02:02","date_gmt":"2026-03-04T11:02:02","guid":{"rendered":"https:\/\/ekfz.uni-goettingen.de\/publikation\/otof-gene-therapy-from-breakthroughs-to-roadmaps-2026\/"},"modified":"2026-03-04T12:28:35","modified_gmt":"2026-03-04T11:28:35","slug":"otof-gene-therapy-from-breakthroughs-to-roadmaps-2026","status":"publish","type":"prp_publik_release","link":"https:\/\/ekfz.uni-goettingen.de\/en\/publikation\/otof-gene-therapy-from-breakthroughs-to-roadmaps-2026\/","title":{"rendered":"OTOF Gene Therapy: From Breakthroughs to Roadmaps"},"content":{"rendered":"<p>Wang Q, Moser T, Petit C, MedComm March 2026.<\/p>\n<p>In a recent study published in Nature Medicine, adeno-associated virus (AAV)-mediated OTOF gene replacement in autosomal recessive nonsyndromic deafness form 9 (DFNB9) patients restored near-physiological hearing and markedly improved speech perception [1]. These results move otoferlin therapy from preclinical promise to a realistic, early-life precision treatment, positioning OTOF as a pathfinder for broader genetic cures for hereditary deafness and motivating scalable trial, manufacturing, and regulatory roadmaps. <\/p>\n","protected":false},"featured_media":0,"template":"","prp_year":[236],"class_list":["post-9083","prp_publik_release","type-prp_publik_release","status-publish","hentry","prp_year-2026-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.4 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>OTOF Gene Therapy: From Breakthroughs to Roadmaps - ekfz<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ekfz.uni-goettingen.de\/en\/publikation\/otof-gene-therapy-from-breakthroughs-to-roadmaps-2026\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"OTOF Gene Therapy: From Breakthroughs to Roadmaps - ekfz\" \/>\n<meta property=\"og:description\" content=\"Wang Q, Moser T, Petit C, MedComm March 2026. 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