{"id":6542,"date":"2025-04-22T08:36:10","date_gmt":"2025-04-22T06:36:10","guid":{"rendered":"https:\/\/ekfz.uni-goettingen.de\/platforms\/"},"modified":"2025-10-17T08:50:59","modified_gmt":"2025-10-17T06:50:59","slug":"platforms","status":"publish","type":"page","link":"https:\/\/ekfz.uni-goettingen.de\/en\/platforms\/","title":{"rendered":"Platforms"},"content":{"rendered":"
[vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column el_id=”zeile2″][vc_empty_space height=”50px”][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column width=”1\/2″][vc_single_image image=”6750″ img_size=”120×120″][vc_column_text]\n

Optogenetic
\nActuators<\/h2>\n[\/vc_column_text][wr_vc_section_title title2=”The integration of genome mining, protein engineering and automated functional testing creates a highly efficient development environment for optogenetic actuators. The systematically collected data provides valuable insights into the opsin fitness landscape and opens up new avenues for data-driven and structure-based protein design – for more precise, more effective therapies of tomorrow.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Platform 1 Optogenetic Actuators” link_url=”https:\/\/ekfz.uni-goettingen.de\/en\/portfolio\/platform-1-optogenetic-actuators\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”6749″ img_size=”120×120″][vc_column_text]\n

Targeted Therapy
\nvia Gene Delivery<\/strong><\/h2>\n[\/vc_column_text][wr_vc_section_title title2=”To develop precise and safe optogenetic treatments, we design adeno-associated viral vectors (rAAV) that are precisely tailored to the requirements of the target cells. Through screening, optimization and targeted combination of capsid variants, we improve specificity, efficiency and biological safety profile. Building on this foundation, we create a scalable, GMP-compliant production process for clinical applications – supported by the expertise of leading research laboratories.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Platform 2 Viral Vector Engineering” link_url=”https:\/\/ekfz.uni-goettingen.de\/en\/portfolio\/platform-2-viral-vector-engineering\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column width=”1\/2″][vc_single_image image=”6748″ img_size=”120×120″][vc_column_text]\n

Understanding how
\nOptogenetics Works<\/h2>\n
<\/div>\n[\/vc_column_text][wr_vc_section_title title2=”Using human organoids, animal models and computer-aided simulations, we develop robust preclinical models to evaluate the safety and efficacy of optogenetic therapies. In silico, we test targeted stimulation paradigms to restore neuronal functions – faster and more animal-friendly. In vitro, we validate vector strategies in human organoids before testing promising approaches in vivo in different species. The close integration of these systems provides a deep, integrated understanding of the mechanism of action and the targeted development of optogenetic treatments.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Platform 3 Disease Modeling” link_url=”https:\/\/ekfz.uni-goettingen.de\/en\/portfolio\/platform-3-disease-modeling\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”6747″ img_size=”120×120″][vc_column_text]\n

Safe Therapies through
\nHypoimmune Optogenetics
\nand Immunomodulation<\/h2>\n
<\/div>\n[\/vc_column_text][wr_vc_section_title title2=”To ensure the tolerability of optogenetic therapies, we systematically analyze tissue changes, immune cell infiltrations and cellular and humoral immune responses after gene transfer. Through histological, serological and cellular examinations, we identify possible immunological triggers and develop strategies to minimize unwanted reactions. The close collaboration of immunological, neuropathological and physiological expertise creates the basis for safe and well-tolerated therapy concepts.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Platform 4 Immunomodulation and Phenotyping” link_url=”https:\/\/ekfz.uni-goettingen.de\/en\/portfolio\/platform-4-immunomodulation-and-phenotyping\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column width=”1\/2″][vc_single_image image=”6746″ img_size=”120×120″][vc_column_text]\n

Developing New
\nTechnologies
\n– Precise Control with Light<\/h2>\n
<\/div>\n[\/vc_column_text][wr_vc_section_title title2=”We develop miniaturized, durable medical devices with maximum light output for targeted optogenetic stimulation. A flexible system of energy and data coupling, integrated control and light conduction enables the precise stimulation of distant target regions. Prototypes for clinical use – robust, adaptable and application-oriented – are developed in close cooperation with industrial partners. The first milestone: a functional design stop for optical cochlear implants by 2028.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Platform 5 Medical Device Engineering” link_url=”https:\/\/ekfz.uni-goettingen.de\/en\/portfolio\/platform-5-medical-device-engineering\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout_grid=”section_layout_grid3″ stukram_section_row_grid=”no” css=”.vc_custom_1746638126723{background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column]
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 1 \u2013 Optogenetic Actuators<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 2 \u2013 Viral Vector Engineering<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 3 \u2013 Disease Modeling<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 4 \u2013 Immunomodulation and Phenotyping<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 5 \u2013 Medical Device Engineering<\/h2>View project<\/i><\/a><\/div><\/div><\/div><\/div><\/div>[vc_empty_space height=”60px”][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

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