{"id":6542,"date":"2025-04-22T08:36:10","date_gmt":"2025-04-22T06:36:10","guid":{"rendered":"https:\/\/ekfz.uni-goettingen.de\/platforms\/"},"modified":"2026-10-12T11:47:21","modified_gmt":"2026-10-12T09:47:21","slug":"platforms","status":"publish","type":"page","link":"https:\/\/ekfz.uni-goettingen.de\/en\/platforms\/","title":{"rendered":"Platforms"},"content":{"rendered":"
[vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column el_id=”zeile2″][vc_empty_space height=”50px”][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column width=”1\/2″][vc_single_image image=”10725″ img_size=”120×120″][vc_column_text]\n

Optogenetic
\nActuators<\/h2>\n[\/vc_column_text][wr_vc_section_title title2=”Durch die Integration von Genom-Mining, Protein-Engineering und automatisierten Funktionstests entsteht eine hocheffiziente Entwicklungsumgebung f\u00fcr optogenetische Aktoren. Die systematisch erfassten Daten liefern wertvolle Einblicke in die Opsin-Fitness-Landschaft und er\u00f6ffnen neue Wege f\u00fcr datengetriebenes und strukturbasiertes Protein-Design \u2013 f\u00fcr pr\u00e4zisere, wirksamere Therapien von morgen.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Plattform 1 Optogenetische Aktuatoren” link_url=”\/portfolio\/plattform-1\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”10727″ img_size=”120×120″][vc_column_text]\n

Targeted Therapy
\nvia Gene Delivery<\/strong><\/h2>\n[\/vc_column_text][wr_vc_section_title title2=”Zur Entwicklung pr\u00e4ziser und sicherer optogenetischer Behandlungen gestalten wir adeno-assoziierte virale Vektoren (rAAV), die exakt auf die Anforderungen der Zielzellen abgestimmt sind. Durch Screening, Optimierung und gezielte Kombination von Kapsidvarianten verbessern wir Spezifit\u00e4t, Effizienz und biologisches Sicherheitsprofil. Aufbauend auf dieser Grundlage entsteht ein skalierbarer, GMP-konformer Produktionsprozess f\u00fcr klinische Anwendungen \u2013 getragen von der Expertise f\u00fchrender Forschungslabore.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Plattform 2 Viral Vector Engineering” link_url=”\/portfolio\/plattform-2\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column width=”1\/2″][vc_single_image image=”10729″ img_size=”120×120″][vc_column_text]\n

Understanding how
\nOptogenetics Works<\/h2>\n
<\/div>\n[\/vc_column_text][wr_vc_section_title title2=”Mithilfe menschlicher Organoide, Tiermodelle und computergest\u00fctzter Simulationen entwickeln wir belastbare pr\u00e4klinische Modelle zur Bewertung von Sicherheit und Wirksamkeit optogenetischer Therapien. In silico testen wir gezielt Stimulationsparadigmen zur Wiederherstellung neuronaler Funktionen \u2013 schneller und tierschonender. In vitro validieren wir Vektorstrategien in menschlichen Organoiden, bevor wir vielversprechende Ans\u00e4tze in vivo in verschiedenen Spezies pr\u00fcfen. Durch die enge Verzahnung dieser Systeme entsteht ein tiefes, integriertes Verst\u00e4ndnis f\u00fcr den Wirkmechanismus und die gezielte Weiterentwicklung optogenetischer Behandlungen.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Plattform 3 Disease Modeling” link_url=”\/portfolio\/plattform-3\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”10731″ img_size=”120×120″][vc_column_text]\n

Safe Therapies through
\nHypoimmune Optogenetics
\nand Immunomodulation<\/h2>\n
<\/div>\n[\/vc_column_text][wr_vc_section_title title2=”Um die Vertr\u00e4glichkeit optogenetischer Therapien zu sichern, analysieren wir systematisch Gewebever\u00e4nderungen, Immunzellinfiltrationen und zellul\u00e4re sowie humorale Immunantworten nach Gen-Transfer. Durch histologische, serologische und zellul\u00e4re Untersuchungen identifizieren wir m\u00f6gliche immunologische Ausl\u00f6ser und entwickeln Strategien, um ungewollte Reaktionen zu minimieren. Die enge Zusammenarbeit immunologischer, neuropathologischer und physiologischer Expertise schafft die Grundlage f\u00fcr sichere und gut vertr\u00e4gliche Therapiekonzepte.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Plattform 4 Immunomodulation and Phenotyping” link_url=”\/portfolio\/plattform-4\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout=”section_grid”][vc_column width=”1\/2″][vc_single_image image=”10733″ img_size=”120×120″][vc_column_text]\n

Developing New
\nTechnologies
\n– Precise Control with Light<\/h2>\n
<\/div>\n[\/vc_column_text][wr_vc_section_title title2=”F\u00fcr die gezielte optogenetische Stimulation entwickeln wir miniaturisierte, langlebige Medizinger\u00e4te mit h\u00f6chster Lichtausbeute. Ein flexibles System aus Energie- und Datenkopplung, integrierter Steuerung und Lichtleitung erm\u00f6glicht die pr\u00e4zise Reizung entfernter Zielregionen. In enger Abstimmung mit Industriepartnern entstehen Prototypen f\u00fcr den klinischen Einsatz \u2013 robust, anpassbar und anwendungsnah. Das erste Etappenziel: ein funktionaler Designstopp f\u00fcr optische Cochlea-Implantate bis 2028.”][\/wr_vc_section_title][vc_empty_space height=”15px”][wr_vc_section_button button_name=”Plattform 5 Medical Device Engineering” link_url=”\/portfolio\/plattform-5\/” size=”-lg” df_class=”col-md-auto”][vc_empty_space height=”60px”][\/vc_column][vc_column width=”1\/2″][\/vc_column][\/vc_row][vc_row row_type=”main-section” stukram_section_layout_grid=”section_layout_grid3″ stukram_section_row_grid=”no” css=”.vc_custom_1746638126723{background-position: center !important;background-repeat: no-repeat !important;background-size: cover !important;}”][vc_column]
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 5 \u2013 Medical Device Engineering<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 4 \u2013 Immunomodulation and Phenotyping<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 3 \u2013 Disease Modeling<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 2 \u2013 Viral Vector Engineering<\/h2>View project<\/i><\/a><\/div><\/div><\/div>
<\/div><\/div><\/div>

Platforms <\/span><\/p>

Platform 1 \u2013 Optogenetic Actuators<\/h2>View project<\/i><\/a><\/div><\/div><\/div><\/div><\/div>[vc_empty_space height=”60px”][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

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