{"id":6526,"date":"2025-04-09T12:11:42","date_gmt":"2025-04-09T10:11:42","guid":{"rendered":"https:\/\/ekfz.uni-goettingen.de\/movement-deficits\/"},"modified":"2025-07-07T14:05:30","modified_gmt":"2025-07-07T12:05:30","slug":"movement-deficits","status":"publish","type":"page","link":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/","title":{"rendered":"Movement Deficits"},"content":{"rendered":"
[vc_row row_type=”main-section” stukram_section_layout=”section_grid” stukram_content_row_opt=”x-gap-32 y-gap-32 layout-pt-md”][vc_column width=”1\/2″][vc_single_image image=”7210″ img_size=”full”][\/vc_column][vc_column width=”1\/2″][vc_column_text]\n

Optical neuropathy
\nand motor deficits<\/strong><\/h2>\n[\/vc_column_text][vc_column_text]Worldwide, approximately 63 million people are affected by vision loss due to optic nerve atrophy and neuropathy, with a similar number suffering from loss of limb functionality. Currently, there are only inadequate treatment options for these disabling conditions. The team at the EKFZ Center for Optogenetic Therapies focuses on developing closed-loop optogenetic brain-computer interfaces (oBCIs) aimed at restoring vision and enabling skilled movements in hand prostheses. The optogenetic manipulation of brain circuits, widely used in basic neuroscience, is still in the early stages of translation into clinical application. Challenges with current commercial BCIs include broad current spread and tissue scarring, which reduce effectiveness shortly after implantation. However, optogenetic stimulation offers a spatially confined and tissue-penetrating solution.<\/p>\n

The EKFZ Center for Optogenetic Therapies is advancing the development of high-density, closed-loop oBCIs. For vision restoration, this involves targeting specific brain areas that remain functional despite optic nerve damage; this is initially being tested on marmoset models. To restore motor and sensory functions of limbs, the approach involves integrating feedback systems into prostheses to simulate sensory inputs controlled by brain activity. These initiatives require close collaboration between various research platforms to refine the technology and ensure it is safe and effective for future clinical trials. The long-term goal is to conduct extensive preclinical trials on non-human primates to pave the way for clinical testing.<\/p>\n

Contact:
\n<\/strong>Prof. Dr. Marcus Jeschke<\/a>
\nProf. Dr. Hansj\u00f6rg Scherberger<\/a>[\/vc_column_text][\/vc_column][\/vc_row]\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row row_type=”main-section” stukram_section_layout=”section_grid” stukram_content_row_opt=”x-gap-32 y-gap-32 layout-pt-md”][vc_column width=”1\/2″][vc_single_image image=”7210″ img_size=”full”][\/vc_column][vc_column width=”1\/2″][vc_column_text] Optical neuropathy and motor deficits [\/vc_column_text][vc_column_text]Worldwide, approximately 63 million people are affected…<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":34,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-6526","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"\nMovement Deficits - ekfz<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Movement Deficits - ekfz\" \/>\n<meta property=\"og:description\" content=\"[vc_row row_type=”main-section” stukram_section_layout=”section_grid” stukram_content_row_opt=”x-gap-32 y-gap-32 layout-pt-md”][vc_column width=”1\/2″][vc_single_image image=”7210″ img_size=”full”][\/vc_column][vc_column width=”1\/2″][vc_column_text] Optical neuropathy and motor deficits [\/vc_column_text][vc_column_text]Worldwide, approximately 63 million people are affected...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/\" \/>\n<meta property=\"og:site_name\" content=\"ekfz\" \/>\n<meta property=\"article:modified_time\" content=\"2025-07-07T12:05:30+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/\",\"url\":\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/\",\"name\":\"Movement Deficits - ekfz\",\"isPartOf\":{\"@id\":\"https:\/\/ekfz.uni-goettingen.de\/en\/#website\"},\"datePublished\":\"2025-04-09T10:11:42+00:00\",\"dateModified\":\"2025-07-07T12:05:30+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Startseite\",\"item\":\"https:\/\/ekfz.uni-goettingen.de\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Movement Deficits\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/ekfz.uni-goettingen.de\/en\/#website\",\"url\":\"https:\/\/ekfz.uni-goettingen.de\/en\/\",\"name\":\"ekfz\",\"description\":\"Else Kr\u00f6ner Fresenius Zentrum f\u00fcr Optogenetische Therapien\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/ekfz.uni-goettingen.de\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Movement Deficits - ekfz","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/","og_locale":"en_US","og_type":"article","og_title":"Movement Deficits - ekfz","og_description":"[vc_row row_type=”main-section” stukram_section_layout=”section_grid” stukram_content_row_opt=”x-gap-32 y-gap-32 layout-pt-md”][vc_column width=”1\/2″][vc_single_image image=”7210″ img_size=”full”][\/vc_column][vc_column width=”1\/2″][vc_column_text] Optical neuropathy and motor deficits [\/vc_column_text][vc_column_text]Worldwide, approximately 63 million people are affected...","og_url":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/","og_site_name":"ekfz","article_modified_time":"2025-07-07T12:05:30+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/","url":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/","name":"Movement Deficits - ekfz","isPartOf":{"@id":"https:\/\/ekfz.uni-goettingen.de\/en\/#website"},"datePublished":"2025-04-09T10:11:42+00:00","dateModified":"2025-07-07T12:05:30+00:00","breadcrumb":{"@id":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/ekfz.uni-goettingen.de\/en\/movement-deficits\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Startseite","item":"https:\/\/ekfz.uni-goettingen.de\/en\/"},{"@type":"ListItem","position":2,"name":"Movement Deficits"}]},{"@type":"WebSite","@id":"https:\/\/ekfz.uni-goettingen.de\/en\/#website","url":"https:\/\/ekfz.uni-goettingen.de\/en\/","name":"ekfz","description":"Else Kr\u00f6ner Fresenius Zentrum f\u00fcr Optogenetische Therapien","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/ekfz.uni-goettingen.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/pages\/6526","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/comments?post=6526"}],"version-history":[{"count":5,"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/pages\/6526\/revisions"}],"predecessor-version":[{"id":7213,"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/pages\/6526\/revisions\/7213"}],"wp:attachment":[{"href":"https:\/\/ekfz.uni-goettingen.de\/en\/wp-json\/wp\/v2\/media?parent=6526"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}